Association Between Antihypertensive Medication Use and Cerebrovascular

 
   Lead Investigator:    Gary Owen
   Institution      :    U Kentucky
   E-Mail           :    gary.owen@uky.edu
   Proposal ID      :    654



   Proposal Description:
   Chronic hypertension is associated with cardiovascular and cerebrovascular disease and has been linked with both cognitive decline and dementia. ??Specifically, hypertension has been associated with brain arteriosclerosis associated with vascular dementia. Diabetes has also been associated with vascular dementia pathology. Furthermore, hypertension and diabetes are associated with each other and often comorbid conditions. Antihypertensive medications, specifically ace inhibitors, calcium channel blockers, and angiotensin receptor blockers, have been shown to decrease cognitive decline in observational studies, while antihypertensive therapy has shown mixed results in randomized trials. ??In this study, our aim is to investigate the association between antihypertensive medication use and cerebrovascular pathology, with a focus on diabetic patients. We hypothesize that antihypertensive treatment will be associated with less vascular burden. We plan to analyze the effects of various antihypertensive medications on brain pathology results in patients with and without diabetes using logistic regression.Chronic hypertension is associated with cardiovascular and cerebrovascular disease and has been linked with both cognitive decline and dementia. ??Specifically, hypertension has been associated with brain arteriosclerosis associated with vascular dementia. Diabetes has also been associated with vascular dementia pathology. Furthermore, hypertension and diabetes are associated with each other and often comorbid conditions. Antihypertensive medications, specifically ace inhibitors, calcium channel blockers, and angiotensin receptor blockers, have been shown to decrease cognitive decline in observational studies, while antihypertensive therapy has shown mixed results in randomized trials. ??In this study, our aim is to investigate the association between antihypertensive medication use and cerebrovascular pathology, with a focus on diabetic patients. We hypothesize that antih